Bioinformatics identification and integrative analysis of ferroptosis-related key lncRNAs in patients with osteoarthritis.

ABSTRACT:

Background

Ferroptosis and dysregulation of long non-coding RNA (lncRNA) have been described to be strictly relevant to the pathogenesis of osteoarthritis (OA). However, the connection between ferroptosis and lncRNA in OA is poorly appreciated. Herein, we investigated the functional contribution of lncRNA markers correlated with the progression of human OA by comprehensive bioinformatics analysis of a panoramic network of competing endogenous RNA (ceRNA) based on ferroptosis-related genes (FRGs).

Methods

FRGs-related competing endogenous RNA (ceRNA) networks were generated using differentially expressed genes based on OA-related whole transcriptome data from the Gene Expression Omnibus (GEO) database via starBase, miRTarBase, and miRWalk databases. The pivotal lncRNAs were a

SUBMITTER: Yang T 

PROVIDER: S-EPMC10500229 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature