Unicentric Castleman's disease associated with malignant cardiac Amyloid-A amyloidosis: a case report.

ABSTRACT:

Background

Unicentric Castleman's disease (UCD), a lymphoproliferative disorder characterized by enlargement of the lymph nodes, is a rare cause of Amyloid-A amyloidosis. While patients usually present with impaired kidney function and proteinuria, heart involvement is neither common nor the main cause of signs and symptoms.

Case summary

We present a patient who was admitted to the hospital for impaired exercise capacity. Diagnostic work-up revealed severe left ventricular hypertrophy suggestive of cardiac amyloidosis. Although Congo red staining of endomyocardial biopsies was initially negative, subsequent immunohistochemical staining against serum amyloid A finally confirmed the diagnosis of cardiac amyloidosis. 18F-fluorodeoxyglucose positron emission tomography/computed

SUBMITTER: Schuetz T 

PROVIDER: S-EPMC10500416 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature