Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood.

ABSTRACT: Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most common cause of cognitive decline. The alarming epidemiological features of Alzheimer's disease, combined with the high failure rate of candidate drugs tested in the preclinical phase, impose more intense investigations for new curative treatments. NRF2 (Nuclear factor-erythroid factor 2-related factor 2) plays a critical role in the inflammatory response and in the cellular redox homeostasis and provides cytoprotection in several diseases including those in the neurodegeneration spectrum. These roles suggest that NRF2 and its directly associated proteins may be novel attractive therapeutic targets in the fight against AD. In this study, through a systemics perspective, we propose an in silico drug repurpo

SUBMITTER: Bourdakou MM 

PROVIDER: S-EPMC10500459 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature