Toll-like Receptor Agonist CBLB502 Protects Against Cisplatin-induced Liver and Kidney Damage in Mice.

ABSTRACT:

Background/aim

CBLB502, a Toll-like receptor-5 agonist derived from Salmonella flagellin, exerts protective roles against irradiation and chemical drugs in mammalian tissues and stimulates tissue regeneration. This study aimed to investigate whether CBLB502 can protect against liver and kidney damage induced by the chemotherapeutic drug cisplatin (CDDP) and the underlying mechanism of the protective effect.

Materials and methods

Mice were pretreated with CBLB502 [0.2 mg/kg, intraperitoneal (i.p.) injection] 0.5 h prior to administration of CDDP (20 mg/kg, i.p. injection), and analyses of the liver and kidney indices, blood biochemistry, and histopathology were performed.

Results

Pretreatment with CBLB502 alleviated CDDP-induced liver and kidney damage. RNA sequencing

SUBMITTER: Niu P 

PROVIDER: S-EPMC10500535 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature