Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.

ABSTRACT:

Rationale

Discriminative stimuli (DS) are cues that predict reward availability. DS are resistant to extinction and motivate drug seeking even after long periods of abstinence. Previous studies have demonstrated that sign-tracking (ST) and goal-tracking (GT) differences in Pavlovian approach predict distinct cue-modulated vulnerabilities to cocaine reinstatement. GT rats show heightened reinstatement to contextual and DS, while ST rats show heightened reinstatement to discrete stimuli. Here we examine whether DS modulate reinstatement after electric barrier-induced abstinence and whether tracking-related relapse vulnerabilities generalize to opioid relapse.

Objectives

We examine whether DS-modulated reinstatement to fentanyl seeking persists in the presence of reduced advers

SUBMITTER: Martin DA 

PROVIDER: S-EPMC10500549 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature