Automated iterative Csp³-C bond formation.

ABSTRACT: Fully automated synthetic chemistry would substantially change the field by providing broad on-demand access to small molecules. However, the reactions that can be run autonomously are still limited. Automating the stereospecific assembly of Csp³-C bonds would expand access to many important types of functional organic molecules¹. Previously, methyliminodiacetic acid (MIDA) boronates were used to orchestrate the formation of Csp²-Csp² bonds and were effective building blocks for automating the synthesis of many small molecules², but they are incompatible with stereospecific Csp³-Csp² and Csp³-Csp³ bond-forming reactions^3-10. Here we report that hyperconjugative and steric tuning pr

SUBMITTER: Blair DJ 

PROVIDER: S-EPMC10500635 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature