NKX3.1 Expression Contributes to Epithelial-Mesenchymal Transition of Prostate Cancer Cells.

ABSTRACT: Studies demonstrate that inflammation synergizes with high-grade aggressive prostate tumor development and ultimately metastatic spread, in which a lot of work has been done in recent years. However, the clear mechanism of inflammation inciting prostate cancer remains largely uncharacterized. Our previous study has shown that the conditioned media (CM)-mediated LNCaP cell migration is partially correlated with the loss of expression of the tumor suppressor NKX3.1. Here, we continue to investigate the inflammation-mediated migration of prostate cancer cells, and the role of NKX3.1 in this process to gain insights into cell migration-related changes comprehensively. Earlier, the model of inflammation in the tumor microenvironment have been optimized by our research group; here, we continue t

SUBMITTER: Saydullaeva I 

PROVIDER: S-EPMC10500679 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature