Genetic relationship between Cryptococcus neoformans var. neoformans strains of serotypes A and D.

ABSTRACT: Cryptococcus neoformans serotypes A and D are responsible for the overwhelming majority of infections in patients with AIDS. The genetic relationship between the serotypes is poorly understood, but there are significant differences in the epidemiology and clinical presentation of serotype A and D infections. We evaluated the genetic relationship between reference C. neoformans strains belonging to serotypes A and D by analyzing their URA5 sequences and restriction fragment length polymorphisms (RFLPs) with the C. neoformans repetitive element 1 (CNRE-1) probe. The results were compared to those previously obtained for isolates from Brazil and New York City by the same typing methods, and dendrograms were generated. Serotype A and D strains produced distinct RFLP patterns consistent with th

SUBMITTER: Franzot SP 

PROVIDER: S-EPMC105008 | biostudies-literature | 1998 Aug

REPOSITORIES: biostudies-literature