Is punctate palmoplantar keratoderma type 1 associated with malignancy? A systematic review of the literature.

ABSTRACT:

Background

An association between punctate palmoplantar keratoderma type 1 (PPPK1) and malignancy has been proposed for decades. Some authors suggest that individuals with PPPK1 should undergo screening for various types of malignancies while others caution that an association is not well-established. In this systematic review, we summarized and evaluated the current evidence for a possible association between PPPK1 and malignancy.

Methods

The review was conducted along PRISMA guidelines. The search used Embase, MEDLINE, Scopus, and the Human Gene Mutation Database up to March 2022. All studies reporting on individuals with the diagnosis of PPPK1 with or without history of malignancy were included. Two authors screened for eligible studies, extracted predefined data, and per

SUBMITTER: Gram SB 

PROVIDER: S-EPMC10500882 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature