Development of a thyroid cancer prognostic model based on the mitophagy-associated differentially expressed genes.

ABSTRACT:

Background

The prevalence of thyroid cancer (ThyC), a frequent malignant tumor of the endocrine system, has been rapidly increasing over time. The mitophagy pathway is reported to play a critical role in ThyC onset and progression in many studies. This research aims to create a mitophagy-related survival prediction model for ThyC patients.

Methods

Genes connected to mitophagy were found in the GeneCards database. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases provided information on the expression patterns of ThyC-related genes. To identify differentially expressed genes (DEGs), R software was employed. The prognostic significance of each DEG was assessed using the prognostic K-M curve. The prognostic model was built using LASSO, ROC, univariate,

SUBMITTER: Sun W 

PROVIDER: S-EPMC10501032 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature