Differential optogenetic activation of the auditory midbrain in freely moving behaving mice.

ABSTRACT:

Introduction

In patients with severe auditory impairment, partial hearing restoration can be achieved by sensory prostheses for the electrical stimulation of the central nervous system. However, these state-of-the-art approaches suffer from limited spectral resolution: electrical field spread depends on the impedance of the surrounding medium, impeding spatially focused electrical stimulation in neural tissue. To overcome these limitations, optogenetic activation could be applied in such prostheses to achieve enhanced resolution through precise and differential stimulation of nearby neuronal ensembles. Previous experiments have provided a first proof for behavioral detectability of optogenetic activation in the rodent auditory system, but little is known about the generation of com

SUBMITTER: Rogalla MM 

PROVIDER: S-EPMC10501139 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature