Identifying Alzheimer's disease and mild cognitive impairment with atlas-based multi-modal metrics.

ABSTRACT:

Introduction

Multi-modal neuroimaging metrics in combination with advanced machine learning techniques have attracted more and more attention for an effective multi-class identification of Alzheimer's disease (AD), mild cognitive impairment (MCI) and health controls (HC) recently.

Methods

In this paper, a total of 180 subjects consisting of 44 AD, 66 MCI and 58 HC subjects were enrolled, and the multi-modalities of the resting-state functional magnetic resonance imaging (rs-fMRI) and the structural MRI (sMRI) for all participants were obtained. Then, four kinds of metrics including the Hurst exponent (HE) metric and bilateral hippocampus seed independently based connectivity metrics generated from fMRI data, and the gray matter volume (GMV) metric obtained from sMRI data, we

SUBMITTER: Long Z 

PROVIDER: S-EPMC10501142 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature