Dysregulation of core neurodevelopmental pathways-a common feature of cancers with perineural invasion.

ABSTRACT: Background: High nerve density in tumors and metastasis via nerves (perineural invasion-PNI) have been reported extensively in solid tumors throughout the body including pancreatic, head and neck, gastric, prostate, breast, and colorectal cancers. Ablation of tumor nerves results in improved disease outcomes, suggesting that blocking nerve-tumor communication could be a novel treatment strategy. However, the molecular mechanisms underlying this remain poorly understood. Thus, the aim here was to identify molecular pathways underlying nerve-tumor crosstalk and to determine common molecular features between PNI-associated cancers. Results: Analysis of head and neck (HNSCC), pancreatic, and gastric (STAD) cancer Gene Expression Omnibus datasets was used to identify differentiall

SUBMITTER: Gonzalez-Castrillon LM 

PROVIDER: S-EPMC10501147 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature