Species- and strain-specific differences in the phagocytosis of Prototheca: insights from live-cell imaging.

ABSTRACT: The genus Prototheca is an extremely unusual group of achlorophyllic, obligately heterotrophic algae. Six species have been identified as pathogens of vertebrates, including cattle and humans. In cattle, P. bovis is the main infectious pathogen and is associated with bovine mastitis. In contrast, human infections typically involve P. wickerhamii and are associated with a spectrum of varying clinical presentations. Prototheca spp. enter the host from the environment and are therefore likely to be initially recognized by cells of the innate immune system. However, little is known about the nature of the interaction between Prototheca spp. and host phagocytes. In the present study, we adopt a live-cell imaging approach to investigate these interactions over

SUBMITTER: Haider MJA 

PROVIDER: S-EPMC10501220 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature