Association between conditioning intensity and height growth after allogeneic hematopoietic stem cell transplantation in children.

ABSTRACT:

Background

The present study aimed to examine the association between the conditioning intensity and height growth in pediatric patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

We reviewed the clinical records of 89 children with malignant diseases who underwent initial allo-HSCT between 2003 and 2021. Height measurements were standardized using standard height charts prepared by the Japanese Society for Pediatric Endocrinology to calculate standard deviation score (SDS). We defined short stature as a height SDS less than -2.0 in that reference. Myeloablative conditioning (MAC) comprised total-body irradiation at more than 8 Gy and busulfan administration at more than 8 mg/kg (more than 280 mg/m² ). Other conditioning

SUBMITTER: Uemura S 

PROVIDER: S-EPMC10501226 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature