ADT-OH synergistically enhanced the antitumor activity of celecoxib in human colorectal cancer cells.

ABSTRACT:

Background

Colorectal cancer is one of the most prevalent cancers in the world, but the research on its prevention, early diagnosis and treatment is still a major challenge in clinical oncology. Thus, there is a pressing requirement to find effective strategies to improve the survival of colon cancer patients.

Methods

Celecoxib has been accounted to be an effective antitumor drug, but may exhibit significant side effects. In recent studies, 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), one of the most commonly used reagents for the synthesis of sustained-release H₂ S donors, has also been reported to inhibit cancer progression by affecting processes such as cell cycle, angiogenesis, and apoptosis. Therefore, we evaluated the therapeutic effect of the comb

SUBMITTER: Xu H 

PROVIDER: S-EPMC10501245 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature