Structural insights into the mechanism of the sodium/iodide symporter.

ABSTRACT: The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I^-) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones-the master regulators of intermediary metabolism. NIS couples the inward translocation of I^- against its electrochemical gradient to the inward transport of Na⁺ down its electrochemical gradient^1,2. For nearly 50 years before its molecular identification³, NIS was the molecule at the centre of the single most effective internal radiation cancer therapy: radioiodide (¹³¹I^-) treatment for thyroid cancer². Mutations in NIS cause congenital hypothyroidism, which must be treated immediately after birth to preve

SUBMITTER: Ravera S 

PROVIDER: S-EPMC10501339 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature