Schizophrenia polygenic risk score and type 2 diabetes onset in older adults with no schizophrenia diagnosis.

ABSTRACT:

Objectives

An association between type 2 diabetes (T2DM) and schizophrenia has long been observed, and recent research revealed presence of shared genetic factors. However, epidemiological evidence was inconsistent, some reported insignificant contribution of genetic factors to T2DM-schizophrenia comorbidity. Prior works studied people with schizophrenia, particularly, antipsychotic-naive patients, or those during the first psychotic experience to limit schizophrenia-related environmental factors. In contrast, we controlled such factors by utilizing a general population sample of individuals undiagnosed with schizophrenia. We hypothesized that if schizophrenia genetics impact T2DM development and such impact is not fully mediated by schizophrenia-related environment, people with hi

SUBMITTER: Shamsutdinova D 

PROVIDER: S-EPMC10501355 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature