Effects of motor cortex neuromodulation on the specificity of corticospinal tract spinal axon outgrowth and targeting in rats.

ABSTRACT:

Background

Neural activity helps construct neural circuits during development and this function is leveraged by neuromodulation protocols to promote connectivity and repair in maturity. Neuromodulation targeting the motor cortex (MCX) strengthens connections for evoking muscle contraction (MEPs). Mechanisms include promoting local MCX and corticospinal tract (CST) synaptic efficacy and also axon terminal structural changes.

Objective

In this study, we address the question of potential causality between neuronal activation and the neuronal structural response.

Methods

We used patterned optogenetic activation (ChR2-EYFP), daily for 10-days, to deliver intermittent theta burst stimulation (iTBS) to activate MCX neurons within the forelimb representation in healthy rats,

SUBMITTER: Yang L 

PROVIDER: S-EPMC10501380 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature