δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.

ABSTRACT: Astrocytes control the formation of specific synaptic circuits via cell adhesion and secreted molecules. Astrocyte synaptogenic functions are dependent on the establishment of their complex morphology. However, it is unknown if distinct neuronal cues differentially regulate astrocyte morphogenesis. δ-Catenin was previously thought to be a neuron-specific protein that regulates dendrite morphology. We found δ-catenin is also highly expressed by astrocytes and required both in astrocytes and neurons for astrocyte morphogenesis. δ-Catenin is hypothesized to mediate transcellular interactions through the cadherin family of cell adhesion proteins. We used structural modeling and biochemical analyses to reveal that δ-catenin interacts with the N-cadherin juxtamembrane domain to promote N-cadheri

SUBMITTER: Tan CX 

PROVIDER: S-EPMC10501387 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature