Identification of genetic variants influencing methylation in brain with pleiotropic effects on psychiatric disorders.

ABSTRACT: Psychiatric disorders affect 29% of the global population at least once in the lifespan, and genetic studies have proved a shared genetic basis among them, although the underlying molecular mechanisms remain largely unknown. DNA methylation plays an important role in complex disorders and, remarkably, enrichment of common genetic variants influencing allele-specific methylation (ASM) has been reported among variants associated with specific psychiatric disorders. In the present study we assessed the contribution of ASM to a set of eight psychiatric disorders by combining genetic, epigenetic and expression data. We interrogated a list of 3896 ASM tagSNPs in the brain in the summary statistics of a cross-disorder GWAS meta-analysis of eight psychiatric disorders from the Psychiatric Genomics

SUBMITTER: Pineda-Cirera L 

PROVIDER: S-EPMC10501479 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature