Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer.

ABSTRACT: Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as an adjuvant for cancer treatment. Importantly there has been an increasing number of studies contributing to the mechanistic understanding of aspirins' anti-tumour effects and these studies continue to inform the potential clinical use of aspirin for both the prevention and treatment of cancer. This review focuses on the emerging role of aspirin as a regulator of metabolic reprogramming, an essential "hallmark of cancer" required to support the increased demand for biosynthetic intermediates needed for sustained proliferation. Cancer cells frequently undergo metabolic rewiring driven by oncogenic pathways such as hypoxia-inducible fac

SUBMITTER: Hoskin AJ 

PROVIDER: S-EPMC10501897 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature