Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.

ABSTRACT: Platelet factors regulate wound healing and can signal from the blood to the brain^1,2. However, whether platelet factors modulate cognition, a highly valued and central manifestation of brain function, is unknown. Here we show that systemic platelet factor 4 (PF4) permeates the brain and enhances cognition. We found that, in mice, peripheral administration of klotho, a longevity and cognition-enhancing protein^3-7, increased the levels of multiple platelet factors in plasma, including PF4. A pharmacologic intervention that inhibits platelet activation blocked klotho-mediated cognitive enhancement, indicating that klotho may require platelets to enhance cognition. To directly test the effects of platelet factors on the brain, we treated mice with vehicle or systemic PF4

SUBMITTER: Park C 

PROVIDER: S-EPMC10501899 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature