Genetic variants in the adenosine triphosphate-binding cassette transporter A1 and risk of age-related macular degeneration.

ABSTRACT: Genetic variants in ABCA1 are associated with higher concentrations of high-density lipoprotein (HDL) cholesterol. Higher HDL cholesterol concentrations are observationally and genetically associated with higher risk of age-related macular degeneration (AMD). However, whether amino acid-changing genetic variants in ABCA1 associated with high HDL cholesterol concentrations confer a higher risk of AMD in the general population is currently unknown. We tested this hypothesis. The study included 80,972 individuals (1,370 AMD cases) from the Copenhagen General Population Study (CGPS) and 9,584 individuals (142 AMD cases) from the Copenhagen City Heart Study (CCHS) with 10 to 18 years of follow-up. We created an HDL cholesterol weighted allele score based on amino acid-changing ABCA1 variants wi

SUBMITTER: Nordestgaard LT 

PROVIDER: S-EPMC10501952 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature