RAB10 promotes breast cancer proliferation migration and invasion predicting a poor prognosis for breast cancer.

ABSTRACT: RAB10, a member of the small GTPase family, has complex biological functions, but its role in breast cancer (BC) remains unclear. The aim of this study was to investigate the relationship between RAB10's role in BC, its biological functions, and BC prognosis. An online database was used to analyze the correlation between differential expression of RAB10 in BC and prognosis. The results of immunohistochemical assays in clinical cohorts were combined with the database analysis. The chi-square test and COX regression were employed to analyze the correlation between RAB10 and pathological features of BC. MTT, Transwell, and wound healing assays were conducted to detect BC cell proliferation, invasion, and metastatic ability. Bioinformatics techniques were employed to explore the correlation be

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC10502149 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature