Ex-utero third trimester developmental changes in functional brain network organization in infants born very and extremely preterm.

ABSTRACT:

Introduction

The latter half of gestation is a period of rapid brain development, including the formation of fundamental functional brain network architecture. Unlike in-utero fetuses, infants born very and extremely preterm undergo these critical maturational changes in the extrauterine environment, with growing evidence suggesting this may result in altered brain networks. To date, however, the development of functional brain architecture has been unexplored.

Methods

From a prospective cohort of preterm infants, graph parameters were calculated for fMRI scans acquired prior to reaching term equivalent age. Eight graph properties were calculated, Clustering Coefficient (C), Characteristic Path Length (L), Modularity (Q), Local Efficiency (LE), Global Efficiency (GE),

SUBMITTER: Cook KM 

PROVIDER: S-EPMC10502339 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature