Coping with stress: How bacteria fine-tune protein synthesis and protein transport.

ABSTRACT: Maintaining a functional proteome under different environmental conditions is challenging for every organism, in particular for unicellular organisms, such as bacteria. In order to cope with changing environments and stress conditions, bacteria depend on strictly coordinated proteostasis networks that control protein production, folding, trafficking, and degradation. Regulation of ribosome biogenesis and protein synthesis are cornerstones of this cellular adaptation in all domains of life, which is rationalized by the high energy demand of both processes and the increased resistance of translationally silent cells against internal or external poisons. Reduced protein synthesis ultimately also reduces the substrate load for protein transport systems, which are required for maintaining the p

SUBMITTER: Njenga R 

PROVIDER: S-EPMC10502375 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature