Choice of Oral Anticoagulant: Outcomes in Atrial Fibrillation Patients Post-Stroke Despite Direct Oral Anticoagulant Use.

ABSTRACT:

Background

For patients with atrial fibrillation who have an ischemic stroke or transient ischemic attack (TIA) despite taking direct oral anticoagulants (DOACs), the optimal strategy for ongoing anticoagulation is unknown.

Methods

Using provincial administrative databases in Alberta, Canada, we compared anticoagulant use before/after the breakthrough stroke/TIA and assessed recurrence of stroke/TIA or bleeding, with consideration of medication adherence. Adherence was defined as the proportion of days covered (PDC) being ≥ 80%.

Results

Among 985 patients, the median age was 80 years (interquartile range 13), with a mean CHADS₂ score of 1.7± 1 prior to the index event. Patients were followed for a median of 643 days (interquartile range 836). Following the

SUBMITTER: Duong E 

PROVIDER: S-EPMC10502439 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature