Pilot Trial Characteristics, Postpilot Design Modifications, and Feasibility of Full-Scale Trials.

ABSTRACT:

Importance

Pilot trials often lead to study design changes in subsequent full-scale trials. Yet, it remains unclear whether these modifications improve the feasibility of the larger trial.

Objective

To compare feasibility estimates between pilot and full-scale trials and identify pilot trial characteristics and modifications associated with equivalent or improved feasibility in the full-scale trial.

Design, setting, and participants

This cohort study used pilot trials published between January 2005 and December 2018 and their corresponding full-scale trials. PubMed was searched for trials on February 19, 2022.

Exposures

Pilot trial characteristics and postpilot trial design modifications.

Main outcomes and measures

The outcome of interest was difference

SUBMITTER: Ying X 

PROVIDER: S-EPMC10502523 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature