SOX9 knockout decreases stemness properties in colorectal cancer cells.

ABSTRACT:

Background

Colorectal cancer (CRC) is a leading cause of death worldwide. SRY-box transcription factor 9 (SOX9) participates in organogenesis and cell differentiation in normal tissues but has been involved in carcinogenesis development. Cancer stem cells (CSCs) are a small population of cells present in solid tumors that contribute to increased tumor heterogeneity, metastasis, chemoresistance, and relapse. CSCs have properties such as self-renewal and differentiation, which can be modulated by many factors. Currently, the role of SOX9 in the maintenance of the stem phenotype has not been well elucidated, thus, in this work we evaluated the effect of the absence of SOX9 in the stem phenotype of CRC cells.

Methods

We knockout (KO) SOX9 in the undifferentiated CRC cell

SUBMITTER: Avendano-Felix M 

PROVIDER: S-EPMC10502562 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature