MRAβ: A multimodal MRI-derived amyloid-β biomarker for Alzheimer's disease.

ABSTRACT: Florbetapir ¹⁸ F (AV45), a highly sensitive and specific positron emission tomographic (PET) molecular biomarker binding to the amyloid-β of Alzheimer's disease (AD), is constrained by radiation and cost. We sought to combat it by combining multimodal magnetic resonance imaging (MRI) images and a collaborative generative adversarial networks model (CollaGAN) to develop a multimodal MRI-derived Amyloid-β (MRAβ) biomarker. We collected multimodal MRI and PET AV45 data of 380 qualified participants from the ADNI dataset and 64 subjects from OASIS3 dataset. A five-fold cross-validation CollaGAN were applied to generate MRAβ. In the ADNI dataset, we found MRAβ could characterize the subject-level AV45 spatial variations in both AD and mild cognitive impairment (MCI). Voxel-wise two-s

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10502620 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature