Regional white matter hyperintensity volume in Parkinson's disease and associations with the motor signs.

ABSTRACT:

Objective

To determine whether white matter hyperintensity (WMH) volumes in specific regions are associated with Parkinson's disease (PD) compared to non-PD controls, and to assess their impact on motor signs through cross-sectional and longitudinal analyses.

Methods

A total of 50 PD participants and 47 age- and gender-matched controls were enrolled. All PD participants were followed up for at least 2 years. To detect regions of greater WMH in the PD, the WMH volume of each region was compared with the corresponding region in the control group. Linear regression and linear mixed effects models were respectively used for cross-sectional and longitudinal analyses of the impact of increases in WMH volume on motor signs.

Results

The PD group had greater WMH volume in the

SUBMITTER: Wu H 

PROVIDER: S-EPMC10502622 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature