Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.

ABSTRACT:

Objective

Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is a challenging neurodevelopmental disease characterized by abundant epileptiform spikes during non-rapid eye movement (NREM) sleep accompanied by cognitive dysfunction. The mechanism of cognitive dysfunction is unknown, but treatment with high-dose diazepam may improve symptoms. Spike rate does not predict treatment response, but spikes may disrupt sleep spindles. We hypothesized that in patients with EE-SWAS: (1) spikes and spindles would be anti-correlated, (2) high-dose diazepam would increase spindles and decrease spikes, and (3) spindle response would be greater in those with cognitive improvement.

Methods

Consecutive EE-SWAS patients treated with high-dose diazepam that met the criteria

SUBMITTER: McLaren JR 

PROVIDER: S-EPMC10502632 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature