Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.

ABSTRACT: Cancer progression is caused by genetic changes and associated with various alterations in cell properties, which also affect a tumor's mechanical state. While an increased stiffness has been well known for long for solid tumors, it has limited prognostic power. It is hypothesized that cancer progression is accompanied by tissue fluidization, where portions of the tissue can change position across different length scales. Supported by tabletop magnetic resonance elastography (MRE) on stroma mimicking collagen gels and microscopic analysis of live cells inside patient derived tumor explants, an overview is provided of how cancer associated mechanisms, including cellular unjamming, proliferation, microenvironment composition, and remodeling can alter a tissue's fluidity and stiffness. In viv

SUBMITTER: Sauer F 

PROVIDER: S-EPMC10502644 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature