Specialized Pro-resolving Mediator Improves Vascular Relaxation via Formyl Peptide Receptor-2.

ABSTRACT:

Background

The resolution of inflammation is an active phenomenon important for switching off inflammatory processes once the harmful stimuli are removed and facilitate the return to homeostasis. Specialized pro-resolving mediators (SPMs), such as lipoxin A4, resolvin D1, and resolvin E1, derived from ω-3 or ω-6 polyunsaturated fatty acids, are crucial for the resolution of inflammation. We hypothesized that SPMs are decreased in hypertension which contributes to the acetylcholine-induced contraction in resistance arteries, which are well known to be mediated by leukotrienes and prostaglandins. Moreover, treatment with SPMs will decrease this contraction via formyl peptide receptor-2 (FPR-2) in resistance arteries from spontaneously hypertensive rats (SHR).

Methods and results</

SUBMITTER: Edwards-Glenn JM 

PROVIDER: S-EPMC10502783 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature