Pyramidal neuron subtype diversity governs microglia states in the neocortex.

ABSTRACT: Microglia are specialized macrophages in the brain parenchyma that exist in multiple transcriptional states and reside within a wide range of neuronal environments^1-4. However, how and where these states are generated remains poorly understood. Here, using the mouse somatosensory cortex, we demonstrate that microglia density and molecular state acquisition are determined by the local composition of pyramidal neuron classes. Using single-cell and spatial transcriptomic profiling, we unveil the molecular signatures and spatial distributions of diverse microglia populations and show that certain states are enriched in specific cortical layers, whereas others are broadly distributed throughout the cortex. Notably, conversion of deep-layer pyramidal neurons to an alternate class iden

SUBMITTER: Stogsdill JA 

PROVIDER: S-EPMC10502800 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature