The m⁶ A reader MhYTP2 negatively modulates apple Glomerella leaf spot resistance by binding to and degrading MdRGA2L mRNA.

ABSTRACT: Glomerella leaf spot (GLS), caused by the fungal pathogen Colletotrichum fructicola, significantly threatens apple production. Some resistances to plant disease are mediated by the accumulation of nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins that are encoded by a major class of plant disease resistance genes (R genes). However, the R genes that confer resistance to GLS in apple remain largely unclear. Malus hupehensis YT521-B homology domain-containing protein 2 (MhYTP2) was identified as an N⁶ -methyladenosine RNA methylation (m⁶ A) modified RNA reader in our previous study. However, whether MhYTP2 binds to mRNAs without m⁶ A RNA modifications remains unknown. In this study, we discovered that MhYTP2 exerts both m⁶ A-depend

SUBMITTER: Guo T 

PROVIDER: S-EPMC10502827 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature