Hyper α2,6-Sialylation Promotes CD4⁺ T-Cell Activation and Induces the Occurrence of Ulcerative Colitis.

ABSTRACT: α2,6-sialylation, catalyzed by α2,6-sialyltransferase (ST6GAL1), plays a pivotal role in immune responses. However, the role of ST6GAL1 in the pathogenesis of ulcerative colitis (UC) remains unknown. ST6GAL1 mRNA is highly expressed in UC tissues compared with the corresponding adjacent normal tissues, and α2,6-sialylation is significantly increased in the colon tissues of patients with UC. The expression of ST6GAL1 and proinflammatory cytokines, such as interleukin (IL)-2, IL-6, IL-17, and interferon-gamma, is also increased. The number of CD4⁺ T cells increases in UC patients. St6gal1 gene knockout (St6gal1^-/- ) rats are established by clustered regularly interspaced short palindromic repeats (CRISPR)-associated gene knockout system. St6gal1 deficiency reduces the l

SUBMITTER: Fan Q 

PROVIDER: S-EPMC10502867 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature