Molecular Parameters Promoting High Relaxivity in Cluster-Nanocarrier Magnetic Resonance Imaging Contrast Agents.

ABSTRACT: We have investigated the mechanism of relaxivity for two magnetic resonance imaging contrast agents that both employ a cluster-nanocarrier design. The first system termed Mn₈Fe₄-coPS comprises the cluster Mn₈Fe₄O₁₂(L)₁₆(H₂O)₄ or Mn₈Fe₄ (1) (L = carboxylate) co-polymerized with polystyrene to form ∼75 nm nanobeads. The second system termed Mn₃Bpy-PAm used the cluster Mn₃(O₂CCH₃)₆(Bpy)₂ or Mn₃Bpy (2) where Bpy = 2,2'-bipyridine, entrapped in ∼180 nm polyacrylamide nanobeads. Here, we investigate the rate of water exchange of the two clusters, and corresponding cluster-nanocarriers, in order to

SUBMITTER: Lyons T 

PROVIDER: S-EPMC10502962 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature