The causal association between systemic inflammatory regulators and primary ovarian insufficiency: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Recent studies have suggested a potential link between systemic inflammatory regulators and primary ovarian insufficiency (POI); however, a causal relationship between them remains unclear. In this study, we explored the causal link between systemic inflammatory regulators and POI risk using a bidirectional, two-sample Mendelian randomization (MR) strategy.

Results

This approach utilized the most extensive genome-wide association study involving 41 systemic inflammatory regulators in a sample of 8,293 Finnish individuals and POI data from the FinnGen consortium (254 cases vs. 118,228 controls). The inverse variance weighting approach served as a primary MR method, and four additional MR techniques (Maximum Likelihood, MR-Egger, Weighted Median, and constrained max

SUBMITTER: Wang J 

PROVIDER: S-EPMC10502980 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature