Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study.

ABSTRACT:

Background

Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and symptoms persist (treatment-resistant depression (TRD)). We aim to investigate inflammation, proxied by C-reactive protein (CRP) levels, and body mass index (BMI) as putative causal risk factors for depression and subsequent treatment resistance, leveraging genetic information to avoid confounding via Mendelian randomisation (MR).

Methods

We used the European UK Biobank subcohort ([Formula: see text]), the mental health questionnaire (MHQ) and clinical records. For treatment resistance, a previously curated phenotype based on general practitioner (GP) records an

SUBMITTER: Karageorgiou V 

PROVIDER: S-EPMC10502981 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature