METTL3 exacerbates insulin resistance in hepatocytes by regulating m⁶A modification of cytochrome P450 2B6.

ABSTRACT:

Background

Insulin resistance (IR) in hepatocytes endangers human health, and frequently results in the development of non-alcoholic fatty liver disease (NAFLD). Research on m⁶A methylation of RNA molecules has gained popularity in recent years; however, the molecular mechanisms regulating the processes of m⁶A modification and IR are not known. The cytochrome P450 (CYP450) enzyme system, which is mainly found in the liver, is associated with the pathogenesis of NAFLD. However, few studies have been conducted on CYP450 related m⁶A methylation. Here, we investigated the role of the methyltransferase METTL3 in exacerbating IR in hepatocytes, mainly focusing on the regulation of m⁶A modifications in CYP2B6.

Methods and results

Analysis

SUBMITTER: Li Y 

PROVIDER: S-EPMC10502999 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature