Causal associations of Sjogren's syndrome with cancers: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Several observational studies have explored the associations between Sjögren's syndrome (SS) and certain cancers. Nevertheless, the causal relationships remain unclear. Mendelian randomization (MR) method was used to investigate the causality between SS and different types of cancers.

Methods

We conducted the two-sample Mendelian randomization with the public genome-wide association studies (GWASs) summary statistics in European population to evaluate the causality between SS and nine types of cancers. The sample size varies from 1080 to 372,373. The inverse variance weighted (IVW) method was used to estimate the causal effects. A Bonferroni-corrected threshold of P < 0.0031 was considered significant, and P value between 0.0031 and 0.05 was considered to be sugge

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10503000 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature