Enhancement of hemostatic properties of Cyclotella cryptica frustule through genetic manipulation.

ABSTRACT:

Background

The silicified cell wall of diatoms, also known as frustule, shows huge potential as an outstanding bio-nanomaterial for hemostatic applications due to its high hemostatic efficiency, good biocompatibility, and ready availability. As the architectural features of the frustule determine its hemostatic performance, it is of great interest to develop an effective method to modify the frustule morphology into desired patterns to further improve hemostatic efficiency.

Results

In this study, the gene encoding Silicalemma Associated Protein 2 (a silicalemma-spanning protein) of Cyclotella cryptica (CcSAP2) was identified as a key gene in frustule morphogenesis. Thus, it was overexpressed and knocked down, respectively. The frustule of the overexpress lines showed no obvi

SUBMITTER: Wang L 

PROVIDER: S-EPMC10503012 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature