Construction of the metabolic reprogramming-associated gene signature for clear cell renal cell carcinoma prognosis prediction.

ABSTRACT:

Background

Metabolism reprogramming is a hallmark that associates tumor growth, metastasis, progressive, and poor prognosis. However, the metabolism-related molecular patterns and mechanism in clear cell renal cell carcinoma (ccRCC) remain unclear. Herein, the purpose of this study was to identify metabolism-related molecular pattern and to investigate the characteristics and prognostic values of the metabolism-related clustering.

Methods

We comprehensively analyzed the differentially expressed genes (DEGs), and metabolism-related genes (MAGs) in ccRCC based on the TCGA database. Consensus clustering was used to construct a metabolism-related molecular pattern. Then, the biological function, molecular characteristics, Estimate/immune/stomal scores, immune cell infiltration,

SUBMITTER: Tai R 

PROVIDER: S-EPMC10503121 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature