Silver nanoparticles-decorated extracellular matrix graft: fabrication and tendon reconstruction performance.

ABSTRACT:

Background

The reconstruction of tendons with large defects requires grafts with high mechanical strength and is often hindered by complications such as infection and adhesion. Hence, grafts combining the advantages of mechanical resilience and antibacterial/antiadhesion activity are highly sought after.

Methods

The silver nanoparticles (GA-Ag NPs) synthesized from gallic acid and silver nitrate were attached to a decellularized extracellular matrix (Decellularized Tendon crosslinking GA-AgNPs, DT-Ag). We examined the histological structure, mechanical property, morphology, Zeta potential, cytotoxicity, antibacterial properties, antioxidant and anti-inflammatory properties, and ability of the DT-Ag to treat tendon defects in animals.

Results

Approximately 108.57 ± 0.9

SUBMITTER: Chen S 

PROVIDER: S-EPMC10503197 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature