Sprayed PAA-CaO₂ nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing.

ABSTRACT: The most common socioeconomic healthcare issues in clinical are burns, surgical incisions and other skin injuries. Skin lesion healing can be achieved with nanomedicines and other drug application techniques. This study developed a nano-spray based on cross-linked amorphous calcium peroxide (CaO₂) nanoparticles of polyacrylic acid (PAA) for treating skin wounds (PAA-CaO₂ nanoparticles). CaO₂ serves as a 'drug' precursor, steadily and continuously releasing calcium ions (Ca²⁺) and hydrogen peroxide (H₂O₂) under mildly acidic conditions, while PAA-CaO₂ nanoparticles exhibited good spray behavior in aqueous form. Tests demonstrated that PAA-CaO₂ nanoparticles exhibited low cytotoxicity and allowed L929 cel

SUBMITTER: Yu H 

PROVIDER: S-EPMC10503269 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature