Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults.

ABSTRACT:

Objective

To evaluate the synergistic effects created by fine particulate matter (PM_2.5) and corticosteroid use on hospitalisation and mortality in older adults at high risk for cardiovascular thromboembolic events (CTEs).

Design and setting

A retrospective cohort study using a US nationwide administrative healthcare claims database.

Participants

A 50% random sample of participants with high-risk conditions for CTE from the 2008-2016 Medicare Fee-for-Service population.

Exposures

Corticosteroid therapy and seasonal-average PM_2.5.

Main outcome measures

Incidences of myocardial infarction or acute coronary syndrome (MI/ACS), ischaemic stroke or transient ischaemic attack, heart failure (HF), venous thromboembolism, atrial fibrillation

SUBMITTER: Josey K 

PROVIDER: S-EPMC10503335 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature