Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry.

ABSTRACT:

Objectives

Type I interferon (IFN) plays a role in the pathogenesis of systemic lupus erythematosus (SLE), but insufficient attention has been directed to the differences in IFN responses between ancestral populations. Here, we explored the expression of the interferon gene signatures (IGSs) in SLE patients of European ancestry (EA) and Asian ancestry (AsA).

Methods

We used gene set variation analysis with multiple IGS encompassing the response to both type 1 and type 2 IFN in isolated CD14+ monocytes, CD19+B cells, CD4+T cells and Natural Killer (NK) cells from patients with SLE stratified by self-identified ancestry. The expression of genes upstream of the IGS and influenced by lupus-associated risk alleles was also examined. Lastly, we employed machine learning (ML) model

SUBMITTER: Rector I 

PROVIDER: S-EPMC10503349 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature