Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice.

ABSTRACT:

Background

Group 2 innate lymphoid cells (ILC2s) are critical mediators of type 2 respiratory inflammation, releasing IL-5 and IL-13 and promoting the pulmonary eosinophilia associated with allergen provocation. Although ILC2s have been shown to promote eosinophil activities, the role of eosinophils in group 2 innate lymphoid cell (ILC2) responses is less well defined.

Objective

We sought to investigate the role of eosinophils in activation of ILC2s in models of allergic asthma and in vitro.

Methods

Inducible eosinophil-deficient mice were exposed to allergic respiratory inflammation models of asthma, such as ovalbumin or house dust mite challenge, or to innate models of type 2 airway inflammation, such as inhalation of IL-33. Eosinophil-specific IL-4/13-deficient mic

SUBMITTER: LeSuer WE 

PROVIDER: S-EPMC10503660 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature